The researchers from the University of Alabama at Birmingham (UAB) conducted an experiment on laboratory rats with estrogen receptor (ER)-negative breast cancer. Trygve Tollefsbol and his team used epigenetics, the study of biological mechanisms that will switch genes on and off. (Related: Breast cancer cells controlled by lifestyle factors, plant nutrient combination and epigenetic changes.)
“One way we can use epigenetics as a powerful tool to fight cancer is through compounds found in our everyday diet,” Tollefsbol, study author and professor from the UAB, said in an article by Nutrition Insight.
He also said that one reason why some researchers avoid combining two or more compounds at a time for research on treatments is because of the fear of negative effects and unpredictable possible interactions.
The researchers fed the rats with two compounds: sulforaphane, which is found in cruciferous vegetables, such as brussel sprouts and polyphenols, which are found in green tea. They picked out the two compounds because they felt that the compounds would work well combined. Sulforaphane and polyphenols may both have biological effects, but still have diverse means for processing these effects that would not stand in the way of each other. In addition, the compounds are commonly found in the daily diet of people and are previously known to prevent cancers.
The compound sulforaphane “turns…Read More